RT Journal Article
SR Electronic
T1 Clinical outcome of COVID-19 in patients with adult congenital heart disease
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 1226
OP 1232
DO 10.1136/heartjnl-2020-318467
VO 107
IS 15
A1 Schwerzmann, Markus
A1 Ruperti-Repilado, Francisco Javier
A1 Baumgartner, Helmut
A1 Bouma, Berto
A1 Bouchardy, Judith
A1 Budts, Werner
A1 Campens, Laurence
A1 Chessa, Massimo
A1 del Cerro Marin, Maria Jesús
A1 Gabriel, Harald
A1 Gallego, Pastora
A1 Garcia-Orta, Rocio
A1 Gonzalez, Ana Elvira
A1 Jensen, Annette Schophuus
A1 Ladouceur, Magalie
A1 Miranda-Barrio, Berta
A1 Morissens, Marielle
A1 Pasquet, Agnes
A1 Rueda, Joaquín
A1 van den Bosch, Annemien E
A1 van der Zwaan, Heleen Berdina
A1 Tobler, Daniel
A1 Greutmann, Matthias
A1 
YR 2021
UL http://heart.bmj.com/content/107/15/1226.abstract
AB Aims Patients with adult congenital heart disease (ACHD) are a potentially vulnerable patient cohort in case of COVID-19. Some cardiac defects may be associated with a poor COVID-19 outcome. Risk estimation in ACHD is currently based on expert opinion. The aim of this study was to collect clinical outcome data and to identify risk factors for a complicated course of COVID-19 in patients with ACHD.Methods Twenty-five ACHD centres in nine European countries participated in the study. Consecutive patients with ACHD diagnosed with COVID-19 presenting to one of the participating centres between 27 March and 6 June 2020 were included. A complicated disease course was defined as hospitalisation for COVID-19 requiring non-invasive or invasive ventilation and/or inotropic support, or a fatal outcome.Results Of 105 patients with a mean age of 38±13 years (58% women), 13 had a complicated disease course, of whom 5 died. In univariable analysis, age (OR 1.3, 95% CI 1.1 to 1.7, per 5 years), ≥2 comorbidities (OR 7.1, 95% CI 2.1 to 24.5), body mass index of >25 kg/m2 (OR 7.2, 95% CI 1.9 to 28.3) and cyanotic heart disease (OR 13.2, 95% CI 2.5 to 68.4) were associated with a complicated disease course. In a multivariable logistic regression model, cyanotic heart disease was the most important predictor (OR 60.0, 95% CI 7.6 to 474.0).Conclusions Among patients with ACHD, general risk factors (age, obesity and multiple comorbidities) are associated with an increased risk of complicated COVID-19 course. Congenital cardiac defects at particularly high risk were cyanotic lesions, including unrepaired cyanotic defects or Eisenmenger syndrome.Data are available upon reasonable request.